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KMID : 0352120140290010047
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Journal of Kyung Hee University
2014 Volume.29 No. 1 p.47 ~ p.52
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Sedative Effects of Dexmedetomidine Compared with Midazolam during Knee Arthroscopic Surgery under Spinal Anesthesia
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Kang Yoo-Jin
Lee Kang-Woo
Park Sung-Wook
Kim Keon-Sik
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Abstract
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Purpose: In spinal anesthesia, adequate sedation offers a number of advantages to both the patients and physician. But there is not the study that comparison of midazolam commonly used sedative and dexmedetomidine relatively new sedative. The purpose of this study was to comparison of sedative effect, and changes in blood pressure, heart rate and oxygen saturation between midazolam and dexmedetomidine under spinal anesthesia.
Methods: Forty four patients with American society of anesthesiologist physical status 1 or 2 that receive arthroscopic surgery under spinal anesthesia separated into two groups to receive midazolam (M group) or dexmedetomidine(D group). After block level is fixed, midazolam was given to the M group and dexmedetomidine was given to the D group. Bispectral index (BIS), modified observer’s assessment of alertness/sedation scale (MOAA/S), mean arterial pressure (MAP), heart rate(HR), and SpO2, were recorded. Sedative drug infusion was stopped when skin suture was finished. Adverse effects were also recorded.
Result: Both drugs provided good sedation without respiratory depression. In M group, HR was significantly higher, and MAP was significantly lower than in D group. And in three cases of D group, there was significant bradycardia after infusion bolus dosage.
Conclusion: We concluded that both drugs provided satisfactory sedation without respiratory depression. Especially midazolam is safe sedative that have cost benefit in the patients without underlying disease. And the further evaluation about safe initial bolus dose of dexmedetomidine under spinal anesthesia is needed.
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KEYWORD
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Dexmedetomidine, Midazolam, Sedative, spinal anesthesia
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